The document describes the agriculture transformation in Argentina during the 1990s, caused by the adoption of transgenic crops (soybean, maize, and cotton) under the no-tillage system. The expansion of this model has been spread not only in the Pampas but also in areas with high biodiversity, opening a new agricultural border to important eco-regions like the Yungas, Great Chaco, and the Mesopotamian Forest. Transgenic cropping has produced transformations over the environment and society. Migration from rural areas, concentration of agribusiness, and loss of food diversity and food sovereignty are some of the consequences at the socioeconomic level. Nutrient depletion, soil structure degradation, potential desertification, and loss of species are some of the results of the overexploitation associated with the monoculture production of the genetically modified (GM) soybean. The rising ecological and social debt that has emerged due to this technology has not detained the expansion, and instead, an important portion of the country is being transformed into a cluster of productive commodities, especially soybean grain, cake, and oils.